鬼臼毒素

分析标准品,HPLC≥98%

Podophyllotoxin

CAS号：518-28-5

分子式：C22H22O8

分子量：414.41

MDL：MFCD00075290

产品介绍

Podofilox (Podophyllotoxin)是微管组装和DNA拓扑异构酶II抑制剂。

熔点：183-184℃(lit.)

沸点：597.9℃ at 760 mmHg

比旋光度：-110.7 o (C=1, CHCL3)

外观：白色针状结晶粉末

溶解性：DMSO : 100 mg/mL (241.31 mM; Need ultrasonic)

储存条件：2-8℃

注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(16篇)

16. [IF=4.5] Lei Chen et al."Self-assembled ROS -responsive podollyllotoxin twin drug nanoparticles for enhanced anticancer therapy."JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY.2025 Mar;105:106650

15. [IF=13.3] Chaozheng Zhang et al."Dual targeting of FR+CD44 overexpressing tumors by self-assembled nanoparticles quantitatively conjugating folic acid-hyaluronic acid to the GSH-sensitively modified podophyllotoxin."CHEMICAL ENGINEERING JOURNAL.2025 Feb;505:159276

14. [IF=3.7] Min Wang et al."Characterizing the impact of podophyllotoxin on pulmonary toxicity and gut-lung microbiota interactions in SD rats based on TEC concept."Microbiology Spectrum.

13. [IF=4.4] Ma Kaiyue et al."Potential mechanisms underlying podophyllotoxin-induced cardiotoxicity in male rats: toxicological evidence chain (TEC) concept."Frontiers in Pharmacology.2024 Sep;15:

12. [IF=5.6] Shengnan Xu et al."Effects of age and tissue of Juniperus sabina L. on its phytochemical characteristics, anti-cholinesterase, antidiabetes, and anti-drug resistant bacteria activities."Frontiers in Plant Science.10.3389/fpls.2023.1174922

11. [IF=5.1] Hongyan Lin et al."Modified Podophyllotoxin Phenoxyacetamide Phenylacetate Derivatives: Tubulin/AKT1 Dual-Targeting and Potential Anticancer Agents for Human NSCLC."JOURNAL OF NATURAL PRODUCTS.2023;XXXX(XXX):XXX-XXX

10. [IF=4.103] Yingyu Ma et al."Redox-responsive self-assembled podophyllotoxin twin drug nanoparticles for enhanced intracellular drug delivery."Biomedical Materials.2023 May;18(4):045019

9. [IF=4.384] Xiu Zhao et al."Preparation, characterization and biological evaluation of β-cyclodextrin-biotin conjugate based podophyllotoxin complex."Eur J Pharm Sci. 2021 May;160:105745

8. [IF=5.221] Zi Cheng-Ting et al."Design, Synthesis, and Biological Evaluation of Novel Biotinylated Podophyllotoxin Derivatives as Potential Antitumor Agents."Front Chem. 2019 Jun;0:434

7. [IF=3.641] Cheng-Ting Zi et al."Synthesis and antitumor activity of novel per-butyrylated glycosides of podophyllotoxin and its derivatives."Bioorgan Med Chem. 2015 Apr;23:1437

6. [IF=5.64] Wu Dousheng et al."Oleanolic Acid Induces the Type III Secretion System of Ralstonia solanacearum."Front Microbiol. 2015 Dec;0:1466

5. Zi, Cheng-Ting, et al. "Synthesis and Anticancer Activity of 4 β-Triazole-podophyllotoxin Glycosides." Natural products and bioprospecting 5.2 (2015): 83-90.

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1.王萍 陈涛 刘永玲 等.响应面法优化桃儿七中鬼臼毒素的热回流提取工艺[J].中药材2012 35(011):1864-1867.