对乙酰氨基酚

分析标准品,HPLC≥99%

Paracetamol，acetaminophen

CAS号：103-90-2

分子式：C8H9NO2

分子量：151.16

MDL：MFCD00002328

别名：扑热息痛; N-(4-羟基苯基)乙酰胺;对羟基乙酰苯胺; 4'-羟基乙酰苯胺; 4-乙酰氨基酚;对乙酰氨基*苯酚; N-(4-羟基苯基)乙酰胺; N-乙酰对氨基酚; 4-乙酰胺基苯酚;乙醯胺酚;查看更多中文别名 收起;Acetaminophen; APAP; Panex; NAPAP; Exdol; N-(4-Hydroxyphenyl)acetamide; Acetamide, N-(4-

产品介绍

Acetaminophen (Paracetamol)是选择性环氧合酶-2 (COX-2)的抑制剂，IC50值为25.8 μM。Acetaminophen是一种有效的肝N-乙酰转移酶2 (NAT2)抑制剂。Acetaminophen是广泛使用的解热和止痛剂。

熔点：168-172 ℃(lit.)

沸点：387.8 ℃ at 760 mmHg

外观：白色结晶性粉末

溶解性：DMSO : 250 mg/mL (1653.88 mM; Need ultrasonic)

H2O : 10 mg/mL (66.16 mM; Need ultrasonic)

敏感性：对光敏感

储存条件：2-8℃

注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(82篇)

82. [IF=5.9] Yanjun Guo et al."The gastrointestinal digestion fates and postprandial plasma fatty acid profiles of four dietary lipids with different unsaturated levels: A comparative study using Sprague-Dawley rats."Food Bioscience.2025 Sep;71:107295

81. [IF=4] Guofang Bi et al."Assessment of the in vitro CYPs Activity in Human Liver Organoids: Development and Validation of a Cocktail Method with LC-MS/MS."DRUG METABOLISM AND DISPOSITION.2025 Jun;:100106

80. [IF=4.2] Xiaolei Miao et al."Determination of Eight Catechins and Four Theaflavins in Qingzhuan Dark Tea of Different Years (1, 5, 9, and 13 Years)."JOURNAL OF FOOD BIOCHEMISTRY.2025 Jun;2025(1):1214060

79. [IF=11.5] Shiyu Chen et al."Nanomedicine-mediated macrophage polarization enhances the iron-depleting effect of desferrioxamine for breast cancer immunotherapy."JOURNAL OF CONTROLLED RELEASE.2025 Aug;384:113956

78. [IF=3] Wenwen Liu et al."Amelioration of Acetaminophen-Induced Hepatic Oxidative Stress and Inflammation by RNAi Targeting Cyp2e1 In Vivo."CURRENT ISSUES IN MOLECULAR BIOLOGY.2025 May;47(5):372

77. [IF=4.9] Weimin Liang et al."Evaluation of pharmacokinetics and metabolism of three marine-derived piericidins for guiding drug lead selection."Chinese Journal of Natural Medicines.2025 May;23:614

76. [IF=2.9] Jinqiu Rao et al."Inactivation of CYP2D6 by Berberrubine and the Chemical Mechanism."BIOCHEMISTRY.2024;XXXX(XXX):XXX-XXX

75. [IF=2.8] Kexian Li et al."An Optimized and Sensitive UHPLC-ESI-Q-TOF/HRMS Demonstrated the Dynamic Profiling of Allantoin, N-trans-Feruloyl-3-Methoxytyramine, and N-p-Coumaroyltyramine from Portulaca oleracea L. In Vivo in Rats."JOURNAL OF SEPARATION SCIENCE.2024

74. [IF=5.7] Pengcheng Jiao et al."Hollow heterostructured CuOx@Co3O4 nanotube arrays for boosting electrochemical glucose detection."Surfaces and Interfaces.2025 Feb;58:105830

73. [IF=4.8] Jianing Qin et al."Sintilimab combined with acetaminophen aggravates liver injury through apoptotic and disturbed bile acid pathways."TOXICOLOGY.2025 Feb;:154106

72. [IF=7.1] Yuejie Zhang et al."A hemicyanine-based dual-modal probe for fluorescence and mass spectrometry imaging of peroxynitrite in biosamples."FREE RADICAL BIOLOGY AND MEDICINE.2025 Apr;:

71. [IF=4.9] Xiutao Yang et al."Surface engineering induced urchin-like CuFe oxides on copper foam for highly sensitive non-enzymatic glucose sensing."COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS.2024 Nov;703:135301

70. [IF=6.7] Jin-Quan Zhao et al."New finding based on Comparative Toxicogenomics Database: Hepatic YY1 mediates drug-induced liver injury."PHYTOMEDICINE.2024 Sep;:156102

69. [IF=6.7] Yongning Lin et al."Microfluidic Engineering of Addressable Multicompartmental Microspheres for Multicellular Systems."ANALYTICAL CHEMISTRY.2024;96(34):13762–13767

68. [IF=4.8] Guoqing Liu et al."Pharmacokinetic study and neuropharmacological effects of atractylenolide Ⅲ to improve cognitive impairment via PI3K/AKT/GSK3β pathway in intracerebroventricular-streptozotocin rats."JOURNAL OF ETHNOPHARMACOLOGY.2024 Oct;333:118420

67. [IF=5.4] Jingbin Chen et al."Neuro-stimulating effect of Citri Reticulata Pericarpium Viride essential oil through regulating Glu/NMDAR on olfactory bulb to improve anxiety-like behavior."JOURNAL OF ETHNOPHARMACOLOGY".2024 May;:118332

66. [IF=4.7] Dan Yang et al."β-Cyclodextrin metal-organic framework as a green carrier to improve the dissolution, bioavailability, and liver protective effect of luteolin."International Journal of Pharmaceutics-X".2024 Jun;7:100250

65. [IF=5.6] Chi Zhang et al."Abrus cantoniensis Hance alleviates APAP-triggered acute liver damage via inhibiting the MAPK and NF-κB signaling pathways in mice."Journal of Functional Foods".2024 May;116:106145

64. [IF=8.2] Zeng Fan-le et al."Neutrophil extracellular traps promote acetaminophen-induced acute liver injury in mice via AIM2."ACTA PHARMACOLOGICA SINICA".2024 Apr;:1-13

63. [IF=5.6] Dan Yang et al."Luteolin-β-CD-MOF prevents against acetaminophen-mediated liver damage by controlling ferroptosis through GSH/GPX4/SLC7A11 signal axis."Journal of Functional Foods".2024 May;116:106138

62. [IF=19] Huijuan Zhang et al."Natural Phenolic-Metal Framework Strengthened Mesona Chinensis Polysaccharides Microgels for Improved Viability of Probiotics to Alleviate the Liver Injury and Gut Microbiota Dysbiosis."ADVANCED FUNCTIONAL MATERIALS".2024 Mar;:2401064

61. [IF=6.7] Shan Wang et al."Insights into antifouling mechanisms of carbon nanomaterials and enhancing performance with polydopamine functionalization for point-of-care propofol monitoring."APPLIED SURFACE SCIENCE".2024 Feb;:159652

60. [IF=5.2] Hua Li et al."Impact of Cooking Methods on Phenolic Acid Composition, Antioxidant Activity, and Starch Digestibility of Chinese Triticale Porridges: A Comparative Study between Atmospheric Pressure and High Pressure Boiling."Foods.2024 Jan;13(2):230

59. [IF=4.3] Zhanning Liang et al."A Smart Portable Sensor with Ratio and Dual-Mode for In-Situ Detection of Nicotine in Tobacco Leaves."IEEE SENSORS JOURNAL.2023 Nov;PP(99):1-1

58. [IF=4.2] Zhaohong Su et al."Electrodeposition of paracetamol oxide for intelligent portable ratiometric detection of nicotine and ethyl vanillin β-D-glucoside."ANALYST.2023 Nov;:

57. [IF=5.5] Jiuyan Chen et al."Mobility of antipyretic drugs with different molecular structures in saturated soil porous media."Environmental Science-Processes & Impacts.2023 Oct;:

56. [IF=5.9] Chunhui Wang et al."Copper Selenide Micro/Nanocrystals on Carbon Paper via Chemical Vapor Deposition Selenylation as Electrodes for Non-enzymatic Glucose Sensing."ACS Applied Nano Materials.2023;XXXX(XXX):XXX-XXX

55. [IF=3.4] Bike Zhang et al."Yueju volatile oil plays an integral role in the antidepressant effect by up-regulating ERK/AKT-mediated GLT-1 expression to clear glutamate."FITOTERAPIA.2023 Sep;169:105583

54. [IF=4.9] Peiya Shen et al."A prediction system: Regulating effect of small-molecule additives on properties of amorphous solid dispersions prepared by hot-melt extrusion technology."EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS.2023 Aug;189:56

53. [IF=0.5] Shanshan Qi et al."The hepatoprotective effect of Sophora viciifolia fruit extract against acetaminophen-induced liver injury in mice."Journal of Applied Biomedicine.2023 May 18

52. [IF=3.571] Jianru Hou et al."A MS-feature-based medicinal plant database-driven strategy for ingredient identification of Chinese medicine prescriptions."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS.2023 May;:115482

51. [IF=4.601] Yuexuan Li et al."Facile and selective separation of anthraquinones by alizarin-modified iron oxide magnetic nanoparticles."JOURNAL OF CHROMATOGRAPHY A.2023 Aug;1702:464088

50. [IF=7.525] Wang Zengbin et al."IL-33/ST2 antagonizes STING signal transduction via autophagy in response to acetaminophen-mediated toxicological immunity."Cell Communication and Signaling.2023 Dec;21(1):1-15

49. [IF=5.195] Ruowei Zhao et al."Pien Tze Huang attenuated acetaminophen-induced liver injury by autophagy mediated-NLRP3 inflammasome inhibition."JOURNAL OF ETHNOPHARMACOLOGY.2023 Mar;:116285

48. [IF=11.467] Han Gao et al."Rational design of a polysaccharide-based viral mimicry nanocomplex for potent gene silencing in inflammatory tissues."JOURNAL OF CONTROLLED RELEASE.2023 May;357:120

47. [IF=5.743] Jingli Yin et al."An Effective Electrochemical Platform for Chloramphenicol Detection Based on Carbon-Doped Boron Nitride Nanosheets."Biosensors-Basel.2023 Jan;13(1):116

46. [IF=5.518] Chunhui Wang et al."One-step synthesis of copper-platinum nanoparticles modified electrode for non-enzymatic salivary glucose detection."COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS.2023 Feb;658:130672

45. [IF=2.65] Qun Wang et al."Mechanisms Underlying the Differences in the Pharmacokinetics of Six Active Constituents of Huangqi Liuyi Decoction between Normal and Diabetic Nephropathy Mouse Models."Evidence-based Complementary and Alternative Medicine.2022 Oct 15;202

44. [IF=5.988] Yadi Zhong et al."Ginsenoside Rc, as an FXR activator, alleviates acetaminophen-induced hepatotoxicity via relieving inflammation and oxidative stress.."Frontiers in Pharmacology.2022 Oct;13:1027731-1027731

43. [IF=5.202] Xie Meinan et al."Response of the Sirtuin/PXR signaling pathway in Mugilogobius chulae exposed to environmentally relevant concentration Paracetamol."AQUATIC TOXICOLOGY.2022 Aug;249:106222

42. [IF=5.859] Na Qiao et al."Silk Fabric Decorated with Thermo-Sensitive Hydrogel for Sustained Release of Paracetamol."MACROMOLECULAR BIOSCIENCE

41. [IF=4.221] Yanni Zhang et al."3D scaffold fabricated with composite material for cell culture and its derived platform for safety evaluation of drugs."Toxicology. 2022 Jan;466:153066

40. [IF=3.935] Hui Jiang et al."Preparation of covalently bonded liposome capillary column and its application in evaluation of drug membrane permeability."J Pharmaceut Biomed. 2022 Feb;209:114513

39. [IF=1.978] Zheng Yao et al.Protective Effect of Fresh/Dry Dandelion Extracts on APAP-Overdose-Induced Acute Liver Injury.Chinese Journal of Integrative Medicine.2021 Nov 24

38. [IF=2.72] Yunfeng Bi et al."Ginsenoside Rg1 and ginsenoside Rh1 prevent liver injury induced by acetaminophen in mice."J Food Biochem. 2021 Aug;45(8):e13816

37. [IF=3] Yong-Shen REN et al."Dandelion polyphenols protect against acetaminophen-induced hepatotoxicity in mice via activation of the Nrf-2/HO-1 pathway and inhibition of the JNK signaling pathway."Chin J Nat Medicines. 2020 Feb;18:103

36. [IF=3.535] Hui Jiang et al."Determination of lipid–water partition coefficient of neutral and ionic drugs by liposome electrokinetic chromatography."Electrophoresis. 2021 Aug;42(14-15):1436-1449

35. [IF=4.092] Shen Pan et al."Emodin Attenuates Acetaminophen-Induced Hepatotoxicity via the cGAS-STING Pathway."Inflammation. 2021 Aug;:1-14

34. [IF=4.221] Zengbin Wang et al."Interleukin 33 mediates hepatocyte autophagy and innate immune response in the early phase of acetaminophen-induced acute liver injury."Toxicology. 2021 May;456:152788

33. [IF=4.616] Huiwen Wang et al."Rapid quality control of medicine and food dual purpose plant polysaccharides by matrix assisted laser desorption/ionization mass spectrometry."Analyst. 2020 Mar;145(6):2168-2175

32. [IF=7.963] Chenzhi Hou et al."Application of multi-parameter population model based on endogenous population biomarkers and flow volume in wastewater epidemiology."Sci Total Environ. 2021 Mar;759:143480

31. [IF=0] Ka Wu et al."Biocharacterization of Heat Shock Protein 90 in Acetaminophen-Treated Livers Without Conspicuous Drug Induced Liver Injury."Cell Physiol Biochem. 2017;43(4):1562-1570

30. [IF=3.049] Te Qi et al."Cytosolic β-glucosidase inhibition and renal blood flow suppression are leading causes for the enhanced systemic exposure of salidroside in hypoxic rats."Rsc Adv. 2018 Feb;8(16):8469-8483

29. [IF=3.197] Ka Wu et al."Ameliorative effectiveness of allicin on acetaminophen-induced acute liver damage in mice."J Funct Foods. 2015 Oct;18:665

28. Wu, Ka, et al. "Biocharacterization of heat shock protein 90 in acetaminophen-treated livers without conspicuous drug induced liver injury." Cellular Physiology and Biochemistry 43.4 (2017): 1562-1570.https:##doi.org/10.1159/000482003

27. Qi, Te, et al. "Cytosolic β-glucosidase inhibition and renal blood flow suppression are leading causes for the enhanced systemic exposure of salidroside in hypoxic rats." RSC advances 8.16 (2018): 8469-8483.10.1039/C7RA13295F

26. Wei, Yingliang, Anting Wang, and Yuanyuan Liu. "Development of a glassy carbon electrode modified with graphene/Au nanoparticles for determination of acetaminophen in pharmaceutical preparation." Russian Journal of Electrochemistry 54.12 (2018): 1141-1147.

25. Wang, Shu, et al. "Evaluation of novel magnetic targeting microspheres loading adriamycin based on carboxymethyl chitosan." Journal of Drug Delivery Science and Technology 55 (2020): 101388.https:##doi.org/10.1016/j.jddst.2019.101388

24. Ali, Adam Yousif Adam, et al. "Exogenous jasmonic acid and humic acid increased salinity tolerance of sorghum." Agronomy Journal 112.2 (2020): 871-884.https:##doi.org/10.1002/agj2.20072

23.陈瑞,周维,张丽,朱高峰,黄静,汤磊.树豆酮酸A对人肝微粒体中5种常见细胞色素P_(450)酶的体外抑制作用研究[J].中国药房,2021,32(02):195-200.

22.杨宇莎,时京珍,雷钟,周威,梁妍,刘杰,郝小燕,杨虹.血人参乙酸乙酯部位对APAP诱导小鼠急性肝损伤的保护作用[J].时珍国医国药,2018,29(04):786-789.

21.心奇,周卢姗,彭心怡,郑慧华,王萍.茄根醇提物治疗Ⅱ度冻伤模型大鼠实验研究[J].浙江中西医结合杂志,2020,30(08):627-630+697.

20.李梦佳,艾尼瓦尔·塔力甫,程路峰,等.赛甫拉合剂对对乙酰氨基酚致大鼠肝损伤的保护作用[J].西北药学杂志, 2019, v.34(03):75-79.

19.蔺良才,赵菲菲,王敏,等.蓑衣莲酮硫酸酯对对乙酰氨基酚诱导小鼠急性肝损伤的保护作用[J].天然产物研究与开发, 2018(5).

18.舒广文,邱韵涵,李薇,付千,谌业珺,邓旭坤.荷叶总生物碱激活肝脏AMPK/Nrf2通路缓解对乙酰氨基酚诱导的小鼠急性肝损伤[J].天然产物研究与开发,2019,31(02):198-203+317.

17.顾心奇,周卢姗,彭心怡,等.茄根醇提物治疗Ⅱ度冻伤模型大鼠实验研究[J].浙江中西医结合杂志, 2020(8).

16.杨朝令,汪宏良,喻昕,等.艾叶多糖预防对乙酰氨基酚肝中毒机理的研究[J].时珍国医国药, 2012, 23(010):2540-2542.

15.徐瑞,刘钊,付千,等.竹节参多糖对对乙酰氨基酚诱导的小鼠肝损伤的保护作用[J].中南民族大学学报(自然科学版), 2020.

14.杨杭,卓虹伊,练心洁,等.灵芝孢子细胞壁降解菌的筛选及鉴定[J].食品研究与开发, 2018(12).

13.李玉娟,李盼盼,孙欣欣,等.模拟失重对大鼠肝脏CYP1A2的影响研究[J].北京理工大学学报, 2018, v.38；No.281(07):110-114.

12.舒广文,邱韵涵,付千,等.桑葚总多糖对对乙酰氨基酚诱导小鼠急性肝损伤的保护作用[J].中南民族大学学报:自然科学版, 2019, 038(003):377-382.

11.南美娟,唐凯,张化为, et al.山茱萸不同部位提取物对急性肝损伤模型小鼠的保肝作用研究[J].中国药房, 2018, v.29;No.635(17):87-91.

10.王喜梅,王颖.对乙酰氨基酚口服液的制备工艺改进及质量研究[J].黑龙江科技信息, 2013(30):28.

9.杨朝令,李仲娟,石金舟, et al.家兔对乙酰氨基酚口服给药的药代动力学研究[J].热带医学杂志, 2013(02):196-198.

8.杨虹,彭芳,刘刚,等.基于脂类代谢组学研究对乙酰氨基酚对小鼠药物性肝损伤的早期毒性[J].中国药房, 2019(15).

7.全正扬,孙震晓.基于斑马鱼模型的何首乌水提物及其主要成分的肝毒性研究[J].中国药物警戒, 2018.

6.杨虹,彭芳,刘刚, et al.基于代谢组学的研究方法探讨毒性剂量对乙酰氨基酚对小鼠血浆氨基酸代谢的影响[J].中药药理与临床, 2020(2).

5.蒋志涛,王雪,王建春,陈晓峰,王建平,潘金火.垂盆草总黄酮及异鼠李素对对乙酰氨基酚诱导的L02细胞损伤的保护作用[J].中国实验方剂学杂志,2018,24(06):121-125.

4.王洋洋 徐明芳 白卫滨 郑春丽 叶蕾 郑琴琴.双水相法制备鳜鱼（Siniperca chuatsi）肌动蛋白及定量分析[J].食品科学2020 41(12):234-242.

3.付千 徐瑞 段欢 等.刺山柑乙酸乙酯部位对APAP诱导肝损伤的保护作用及体外抗氧化活性测定[J].时珍国医国药2019 30(03):14-17.

2.蒋志涛 吕玲燕 王雪 等. UPLC-MS/MS法测定对乙酰氨基酚栓的含量[J].西北药学杂志2018(4).

1.徐冰洁 徐斌 杜海杰 等. SPE-HPLC法同时测定水中3种典型PPCPs[J].环境科学与技术2017 040(011):37-41.

从2011年开始我们致力于在生命科学领域、生物医学实验技术及论文润色服务，协助客户各类实验服务及论文润色十多年，是您值得信赖的科研合作伙伴!

如果您受时间、试验条件等限制而无法完成您的课题研究，欢迎您与我们联系。

实验技术服务：